* Sgt Fury and His Howling Commandos #1–167 (May 1963–December 1981)
* Shadow Riders #1–4
* Shadowmasters #1–4
* Shadow & Light #1–3
* Shanna the She-Devil #1–5
* She-Hulk Volume 1 #1–12
* She-Hulk Volume 2 #1—
* Sheena #1–2
* Shogun Warriors #1–20 (February 1979–September 1980)
* The Shroud #1–4
* Silent War #1 (2007)
* Silver Sable & the Wild Pack #1–35
* Silver Surfer Volume 1 #1–18
* Silver Surfer Volume 2 #1
* Silver Surfer Volume 3 #1–146
* Skull the Slayer #1–8
* Slapstick #1–4
* Sledge Hammer! #1–2
* Soldier X #1–12
* Solo #1–4
* Solomon Kane #1–6
* Son of Satan #1–8
* Space Squadron #1–5 (continues as Space Worlds)
* Space Worlds #6 (continues from Space Squadron)
* Spaceknights #1–5
* Spaceman #1–6
* Special Marvel Edition #1–16 (continues as Master of Kung-Fu)
* Spectacular Scarlet Spider #1–2 (November 1995–December 1995)
* Spectacular Spider-Man Volume 1 #1–263
* Spectacular Spider-Man Volume 2 #1–27
* Speedball #1–11
* Spellbound Volume 1 #1–34
* Spellbound Volume 2 #1–6
* Spider-Man Unlimited Volume 2 #1–7
* Spider-Man Unlimited Volume 3 #1—
* Spider-Woman Volume 1 #1–50 (April 1978–June 1983)
* Spider-Woman Volume 2 #1–4
* Spider-Woman Volume 3 #1–18
* Spider-Woman: Origin #1–5
* Spidey Super Stories #1–57
* Spitfire and the Troubleshooters #1–9 (continues as Code Name: Spitfire)
* Spoof #1–5
* Sport Stars #1 (continues as Sports Action)
* Star Comics Magazine #1–13
* Star Masters #1–3
* Star Wars #1–107 (July 1977–September 1986)
* Star Wars Annual #1-3 (December 1979-December 1983)
* Starriors #1–4
* Starstruck #1–6
* Storm #1–4
* Strange Combat Tales #1–4
* Strange Stories of Suspense #5–16 (continues from Rugged Action)
* Strange Tales Volume 1 #1–168 (June 1951–May 1968); #169–188 (September 1973–November 1976)
* Strange Tales Volume 2 #1–19 (April 1987–October 1988)
* Strange Tales Volume 3 #1–4 (September 1998–October 1998)
* Strange Tales Annual Volume 1 #1–2 (1962–1963)
* Strange Tales: Dark Corners #1 (May 1998)
* Strange Tales of the Unusual #1–11 (December 1955–August 1957)
* Strange Worlds #1–5
* Strawberry Shortcake #1–7
* Stray Toasters #1–4
* Strikeforce: Morituri #1–31
* Strikeforce: Morituri: Electric Undertow #1–5
* Stryfe's Strike File #1
* Sub-Mariner Volume 1 #1–72 (May 1968–September 1974)
* Sub-Mariner Volume 2 #1–4 (September 1984–December 1984)
* Sub-Mariner Comics #1–42
* Sunfire & Big Hero 6 #1–3
* Super Soldiers #1–8
* Super-Villain Team-Up #1–17 (August 1975–June 1980)
* Supernatural Thrillers #1–15
* The Supernaturals #1–4
* Supreme Power #1–18. Becomes Squadron Supreme
* Suspense #1–29
* Swords of the Swashbucklers #1–12